The universality of gravity (1g) in our daily lives makes it difficult
to appreciate its importance in morphology and physiology. Bone and m
uscle support systems were created, cellular pumps developed, neurons
organised and receptors and transducers of gravitational force to biol
ogically relevant signals evolved under 1g gravity. Spaceflight provid
es the only microgravity environment where systematic experimentation
can expand our basic understanding of gravitational physiology and per
haps provide new insights into normal physiology and disease processes
. These include the surprising extent of our body's dependence on perc
eptual information, and understanding the effect and importance of for
ces generated within the body's weightbearing structures such as muscl
e and bones. Beyond this exciting prospect is the importance of this w
ork towards opening the solar system for human exploration. Although b
oth appear promising, we are only just beginning to taste what lies ah
ead.