LACK OF AGE-RELATED DIFFERENCES IN TEMPORAL-LOBE VOLUME OF VERY HEALTHY-ADULTS

PURPOSE: To evaluate age-related differences in temporal and supratemp oral brain regions in carefully selected, very healthy men 19 to 92 ye ars of age. METHODS: MR quantification of brain regions used image seg mentation into cerebrospinal fluid and brain matter based on nonlinear modeling of pixel intensity distributions. RESULTS: There was a signi ficant age-related decrease (approximately 1% per decade) of posterior frontal lobe volume, but not of temporal lobe volume. The mean volume of the right temporal lobe was significantly greater than the left, a nd this relation did not change with age. CONCLUSION: In very healthy aging, the Volume of the temporal lobes remains constant over the age range of human life.