Slow hemodialysis (HD) was performed for 10 h during the day in 11 cri
tically ill patients with renal failure. The dialysis method was a mod
ification of the pump-driven continuous venovenous HD. A nonsterile bi
carbonate-containing hemodialysate was passed into the EVAL membrane d
ialyzer at a flow rate of 30 ml/min. No patient developed further hemo
dynamic instability during the treatment. The serum urea level was mai
ntained below 20 mmol/l within 4 days of initiating the treatment. It
allowed the patients to rest without interruption at night. This metho
d was safely conducted by general nursing staff under the supervision
of nephrologists on duty during the day. This schedule offers an appro
ach to renal replacement therapy for hemodynamically unstable patients
without any potential problem in the extracorporeal circulation at ni
ght.