A CASE OF LIPOPROTEIN GLOMERULOPATHY SUCCESSFULLY TREATED WITH PROBUCOL

A 54-year-old woman presented proteinuria and severe hyperlipoproteine mia, She had type III hyperlipoproteinemia with the phenotype E2/2. Re nal biopsy specimen revealed lipoprotein thrombi within the glomerular capillary lumina without tubulointerstitial lesion and deposition of IgA in the mesangium and peripheral capillary loops, indicating lipopr otein glomerulopathy with IgA nephropathy. Treatment with probucol res ulted in the improvement of both hyperlipoproteinemia and proteinuria with the disappearance of the lipoprotein thrombi in the glomerular ca pillary without any change in the mesangial IgA deposition. The data s uggest that probucol may be effective against the early stage of lipop rotein glomerulopathy with less lipoprotein thrombi and without tubulo interstitial damage.