TUMOR-CYTOTOXICITY AND PRODUCTION OF INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR FROM BLOOD MONOCYTES OF CERVICAL-CARCINOMA PATIENTS

Authors
NADKARNI JJ DE AK JHAVER KJ KAMAT MR
Citation
Jj. Nadkarni et al., TUMOR-CYTOTOXICITY AND PRODUCTION OF INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR FROM BLOOD MONOCYTES OF CERVICAL-CARCINOMA PATIENTS, Neoplasma, 41(2), 1994, pp. 123-128
Citations number
36
Categorie Soggetti
Oncology
Journal title
Neoplasma → ACNP
ISSN journal
00282685
Volume
41
Issue
2
Year of publication
1994
Pages
123 - 128
Database
ISI
SICI code
0028-2685(1994)41:2<123:TAPOIA>2.0.ZU;2-G
Abstract
To assess the functional integrity of monocytes in patients with cervi cal carcinoma, cytotoxic potential of peripheral blood monocytes and t heir ability to secrete interleukin-1 (IL-1) and tumor necrosis factor -alpha (TNF-alpha) after activation with different stimulating agents were studied. Comparable Levels of monocyte-mediated cytotoxicity were observed in healthy donors and patients. The production of IL-1 and T NF-alpha by monocytes of healthy donors and patients was similar indic ating no defect in monocyte functions in these patients.