THE TRANDOLAPRIL CARDIAC EVALUATION (TRACE) STUDY - RATIONALE, DESIGN, AND BASE-LINE CHARACTERISTICS OF THE SCREENED POPULATION

Authors
VIDEBAEK J HOJBERG S WEIL H ANDERSEN IM BAGGER H PEDERSEN OD NORBY J BENGTSSON B POULSEN K KOLENDORF K KROGSGAARD N ROLIGHED J LYNGBORG K SONNE B KOBER L SNORGAARD MN RAAE D KJAERGAARD JJ LOVSCHALL S DIERNAES E HANSEN T KORUP E NIELSEN L AGNER E PETERSEN JZ WIEMANN O HORNUM L KLARHOLT E VEJBYCHRISTENSEN H NIELSEN SS RAFT A SAUER H HOJRIIS I RONNE K HENRIKSEN A PETERSEN EL MADSEN E SORENSEN P SEJERSEN H GRONLUND B BREUNING L CHRISTIANSEN J HANSEN HHT MORK H GRONHOJ B CHRISTIANSEN I GYEMOSE E JANICHE H MADSEN J STABEL S RASMUSSEN SL MEIER K SKOV N FABER O NIELSEN HV NIELSEN PK RALFSKIAER N HOLMGAARD B BUSTOFT D LINDBJERG IF RASMUSSEN S BING J WESTERGAARD M JACOBSEN JO SCHEIBEL M HAAHR V MANSFELD GB FENGER V ASKLUND M OLESEN C GYLDENKERNE N SEVERINSEN B LOWENSTEIN G METAIS I DIETRICHSON O ACKERMANN R HUNDBORG B KOCH L GARDE K BURCHARDT H RASMUSSEN S WINTHEREIK M LUGGIN H VENNERVALD K CHRISTENSEN I AGERHOLM L BORGESEN I FELSBY M CLAUSEN C MAY O GLESNER P ELIASEN P LESSING M LOMHOLT J KJOLLERHANSEN L BRONS M ANDERSEN J SAEKMOSE S ALBRECHTSEN E LAURIDSEN M DORFF B PETERSEN LP FRITZHANSEN P TORPPEDERSEN C HILDEBANDT P WENSELL K JORGENSEN U MADSEN EB OTTESEN M SKAGEN K HOST U NIELSEN F THERKELSEN A STEINMETZ E RASMUSSEN K MIKKELSEN G KJOLLER E JORGENSEN S JUUL J RASMUSSEN I SORENSEN GV HANSEN C TOUGARD N THYGESEN K SOGAARD P NORGAARD A PEDERSEN L NIELSEN BL NIELSEN JS TVESKOV C AUCLERT L COLE DS
Citation
J. Videbaek et al., THE TRANDOLAPRIL CARDIAC EVALUATION (TRACE) STUDY - RATIONALE, DESIGN, AND BASE-LINE CHARACTERISTICS OF THE SCREENED POPULATION, The American journal of cardiology, 73(10), 1994, pp. 30000044-30000050
Citations number
17
Categorie Soggetti
Cardiac & Cardiovascular System
Journal title
The American journal of cardiology → ACNP
ISSN journal
00029149
Volume
73
Issue
10
Year of publication
1994
Pages
30000044 - 30000050
Database
ISI
SICI code
0002-9149(1994)73:10<30000044:TTCE(S>2.0.ZU;2-Q
Abstract
The TRAndolapril Cardiac Evaluation (TRACE) study is evaluating the ef fect of angiotensin-converting enzyme inhibition with trandolapril on mortality (overall and cardiovascular) and cardiovascular morbidity in patients surviving myocardial infarction (MI) with reduced left ventr icular (LV) function. TRACE is a randomized, double-blind, placebo con trolled study conducted in 27 centers in Denmark. Eligible patients ha d a MI verified by elevated cardiac enzymes, electrocardiographic chan ges, and/or chest pain as well as reduced LV function, as shown by ele ctrocardiographic evaluation of wall motion index less than or equal t o 1.2. (A wall motion index less than or equal to 1.2 approximates to a left ventricular ejection fraction less than or equal to 35%.) Patie nts with residual ischemia and/or heart failure were not excluded. Tra ndolapril or placebo was added to conventional therapy 3-7 days after MI. Between May 1990 and June 1992, 6,674 patients (7,010 infarctions) were screened. A total of 2,614 patients had a wall motion index less than or equal to 1.2; of these, 1,749 were included. Overall 1-year m ortality of the patients entered into the study was 24%. Treatment wil l be continued for 2-4 years (mean, 3 years), ending In mid 1994. The design and organization of the study, the outcome of screening, and de mographic features of the screened population are described.