LINKAGE ANALYSIS OF FAMILIES WITH SEVERE CHILDHOOD AUTOSOMAL RECESSIVE MUSCULAR-DYSTROPHY IN MOROCCO INDICATES GENETIC HOMOGENEITY OF THE DISEASE IN NORTH-AFRICA

Authors
ELKERCH F SEFIANI A AZIBI K BOUTALEB N YAHYAOUI M BENTAHILA A VINET MC LETURCQ F BACHNER L BECKMANN J CAMPBELL KP TOME FMS FARDEAU M KAPLAN JC
Citation
F. Elkerch et al., LINKAGE ANALYSIS OF FAMILIES WITH SEVERE CHILDHOOD AUTOSOMAL RECESSIVE MUSCULAR-DYSTROPHY IN MOROCCO INDICATES GENETIC HOMOGENEITY OF THE DISEASE IN NORTH-AFRICA, Journal of Medical Genetics, 31(4), 1994, pp. 342-343
Citations number
15
Categorie Soggetti
Genetics & Heredity
Journal title
Journal of Medical Genetics → ACNP
ISSN journal
00222593
Volume
31
Issue
4
Year of publication
1994
Pages
342 - 343
Database
ISI
SICI code
0022-2593(1994)31:4<342:LAOFWS>2.0.ZU;2-X
Abstract
It has been previously shown in Tunisian and Algerian families that th e locus for SCARMD maps to the proximal part of 13q, and in Algerian f amilies that the disease is associated with deficiency of the 50 kDa d ystrophin associated glycoprotein (50DAG). We have tested this linkage in six families from Morocco where this disease is also prevalent. In one family the 50DAG was tested and found to be negative in a muscle biopsy. Our results showed similar linkage in this country, with stati stical tests indicating genetic homogeneity between the three Maghreb countries.