Vv. Lazarev et al., ULTRAVIST - A DRUG OF CHOICE FOR CHILDREN WITH RENAL DYSFUNCTION DURING RADIOPAQUE STUDIES, VESTNIK ROSSIISKOI AKADEMII MEDITSINSKIKH NAUK, (3), 1994, pp. 47-50
The nonionic radioopaque ultravist and the high-molar radioopaque vero
graffin were studied for their effects on the blood osmotic status of
children with lower renal concentrating function. A total of 36 childr
en aged 8 months to 12 years who had pyelonephritis, hydronephrosis an
d renal injury at their acute stage were studied angiographically unde
r general anesthesia. The radioopaque was injected in a mean dose of 2
ml/kg for 2-3 sec. Ultravist was found to have a less osmotic action
on the blood osmotic status than did verograffin. The changes in the d
etectable major blood osmotic parameters: sodium, potassium, glucose,
urea, creatine were less pronounced. Plasma osmolality was moderately
increased with ultravist and much higher than its normal values with v
erograffin at min 1 after its administration and at hour 2 of the stud
y. Ultravist is preferable as a radiopaque used in children with decre
ased renal concentrating function.