CLONING OF A T-CELL GROWTH-FACTOR THAT INTERACTS WITH THE BETA-CHAIN OF THE INTERLEUKIN-2 RECEPTOR

Authors
GRABSTEIN KH EISENMAN J SHANEBECK K RAUCH C SRINIVASAN S FUNG V BEERS C RICHARDSON J SCHOENBORN MA AHDIEH M JOHNSON L ALDERSON MR WATSON JD ANDERSON DM GIRI JG
Citation
Kh. Grabstein et al., CLONING OF A T-CELL GROWTH-FACTOR THAT INTERACTS WITH THE BETA-CHAIN OF THE INTERLEUKIN-2 RECEPTOR, Science, 264(5161), 1994, pp. 965-968
Citations number
27
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Science → ACNP
ISSN journal
00368075
Volume
264
Issue
5161
Year of publication
1994
Pages
965 - 968
Database
ISI
SICI code
0036-8075(1994)264:5161<965:COATGT>2.0.ZU;2-C
Abstract
A cytokine was identified that stimulated the proliferation of T lymph ocytes, and a complementary DNA clone encoding this new T cell growth factor was isolated. The cytokine, designated interleukin-15 (IL-15), is produced by a wide variety of cells and tissues and shares many bio logical properties with IL-2. Monoclonal antibodies to the beta chain of the IL-2 receptor inhibited the biological activity of IL-15, and I L-15 competed for binding with IL-2, indicating that IL-15 uses compon ents of the IL-2 receptor.