The occurrence of bullous pemphigoid (BP) in patients with multiple sc
lerosis (MS) is uncommon. The aetiology is not clear and several abnor
malities of the immune system are reported in both pathologies. We rep
ort one additional case in a 40-year-old woman with a 15-year history
of MS. BP was confirmed histologically and immunologically. The therap
y with steroids was successful and no recurrence of BP was observed af
ter a six month follow-up.