MATHEMATICAL-MODELING OF ERYTHROPOIETIN THERAPY IN UREMIC ANEMIA - DOES IT IMPROVE COST-EFFECTIVENESS

This paper describes the improvements in r-HuEPO therapy of uremic pat ients that may be obtained by using a mathematical model of patient re sponse together with a delivery control strategy derived from the theo ry of industrial control. A mathematical model of r-HuEPO action is pr esented, and its applicability to dialytic patients is shown. Moreover , a new statistical technique for identifying the parameters of the ma thematical model analyzing a patient population is summarized, and a c ontrol strategy for r-HuEPO delivery in uremic patients based on a Fuz zy Set Controller is introduced. Some results obtained from simulation , are presented.