COMPARATIVE METABOLISM OF DELTAMETHRIN AND 3-PHENOXYBENZOIC ACID IN CHICKENS

A comparative metabolism of [benzyl C-14]deltamethrin and 3-phenoxyben zoic acid (3-PBacid) was carried out in chickens. The effect of oral a nd intravenous route of administration was also investigated. There wa s no difference in the metabolic profile of [C-14] portion of deltamet hrin and 3-PBacid. Similarly, no effect on the nature of metabolites e xcreted due to mode of administration was observed. Biotransformation of orally dosed compounds did not occur in the intestine, but were abs orbed and metabolized by liver (deltamethrin) and kidney (3-PBacid). 3 -PBacid, the primary metabolite of deltamethrin, was readily metaboliz ed into 3-hydroxy benzoic acid (3-HO-Bacid) which is conjugated with a variety of endogenous substances to form sulphates, glucuronides,buty l ester and peptides. HPLC and LC-Ms methods were used to ascertain th e structures of metabolites