A STUDY OF SHEAR AND COMPRESSION DEFORMATIONS ON HYDROPHILIC GELS OF TRETINOIN

Authors
LUCERO MJ VIGO J LEON MJ
Citation
Mj. Lucero et al., A STUDY OF SHEAR AND COMPRESSION DEFORMATIONS ON HYDROPHILIC GELS OF TRETINOIN, International journal of pharmaceutics, 106(2), 1994, pp. 125-133
Citations number
36
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
International journal of pharmaceutics → ACNP
ISSN journal
03785173
Volume
106
Issue
2
Year of publication
1994
Pages
125 - 133
Database
ISI
SICI code
0378-5173(1994)106:2<125:ASOSAC>2.0.ZU;2-W
Abstract
A theological study of hydrophilic gels of Carbomer(R) 940 with tretin oin as the drug, and ascorbic acid as an antioxidant, has been carried out. At the same time, the effect of storage time has been determined . Both shear and compression deformations were applied. From the resul ts obtained, correlations between both types of deformation have been established. The results were statistically significant between shear and compression stresses, and between shear stress and area of spreadi ng.