Background: Primary antiphospholipid antibody syndrome is a clinical e
ntity that may threaten the health of both fetus and mother. Case: We
report a fatal case of primary antiphospholipid antibody syndrome in a
woman who developed catastrophic disease due to multisystem thrombosi
s in the postpartum period following a fetal death. Three years before
her admission, primary antiphospholipid antibody syndrome was diagnos
ed on the basis of high titers of immunoglobulin G anticardiolipin ant
ibody, a positive lupus anticoagulant, a false-positive VDRL, and fibr
in deposits in the biopsy of a palmar lesion. Conclusion: The physicia
n must recognize the potentially catastrophic complications of pregnan
cy and the postpartum period in patients with antiphospholipid antibod
ies, and appropriate patient counseling should be provided.