The technique of catheterization of the urinary bladder, an important
clinical skill for the diagnosis of urinary tract disorders, has not b
een described for the ferret. The bladder was catheterized in 23 ferre
ts (10 intact females; 11 spayed females; and 2 intact males) using a
31/2 French, red rubber urethral catheter fitted with a steel wire sty
let. Ferrets were anaesthetized with isoflurane or ketamine (30 mg/kg
IM) and xylazine (3 mg/kg IM). Females were positioned in ventral recu
mbency with the rear quarters elevated by a rolled surgical towel. The
urethra was catheterized by direct visualization of the external uret
hral orifice using a vaginal speculum. The orifice was approximately I
cm cranial to the clitoral fossa on the ventral floor of the vestibul
e. Blind passage was used in several spayed females. In males, the dis
tal end of the penis was exteriorized from the prepuce and the externa
l urethral orifice cannulated without stylet. No difficulty was encoun
tered in advancing the catheter past the os penis. This catheterizatio
n technique allows urinary tract access for urine collection, pneumocy
stography, contrast cystography, double contrast cystography, and urin
e output determination in pharmacologic studies or in critical care of
debilitated animals.