EVALUATION OF MONOCLONAL ANTI-GLYCOPHORIN-B AS AN UNUSUAL ANTI-S

Background: Monoclonal antibody 148 is a murine monoclonal anti-glycop horin B that preferentially reacts with S+ human red cells. Study Desi gn and Methods: Serologic and immunochemical studies were performed us ing red cells with various phenotypes. Results: These studies reveal t hat this monoclonal antibody is unusual in that it fails to agglutinat e S+ TSEN+ red cells and agglutinates S- St(a+) and S- Dantu+ red cell s. Conclusion: These results allow the prediction of the glycophorin c omposition of GP.Hop (Mi.IV) red cells.