HYDRODYNAMIC MOTIONS OF LARGE MOLECULES

Advances in the theory and simulation of the hydrodynamic motion of la rge biological molecules have been made in three major areas. The firs t of these is the important connection between the diffusive motion of molecules and their biochemical reactions, for which Brownian dynamic s simulation theory has been employed to predict reaction rates in whi ch diffusion plays a dominant role. Second is the nature of hindered d iffusion of large molecules in crowded solutions such as exist in vivo . Third is the continued work on realistic inclusion of internal flexi bility in treatments of macromolecular transport.