Plants interact with their environment by producing a diverse array of
secondary metabolites. Many of these compounds are valued for their m
edicinal, industrial or agricultural properties. Other secondary produ
cts are toxic or otherwise undesirable and can reduce the commercial v
alue of crops. Gene transfer technology offers new opportunities to mo
dify directly plant secondary product synthesis through metabolic engi
neering. This article reviews some of the strategies which have been u
sed to increase or decrease the synthesis of specific plant metabolite
s, as well as methods for expanding the biosynthetic capabilities of i
ndividual species.