Two cases of Lambert-Eaton syndrome are reported, one associated with
a small cell lung carcinoma, the other without any etiology at the tim
e of the study. None of these cases showed significant titers of calci
um channel autoantibodies. The heterogeneity of the Lambert-Eaton synd
rome and the responsibility of the autoantibodies detected by immunopr
ecipitation of the voltage-gated calcium channel in the occurrence of
the neuromuscular block are discussed.