EFFECT OF POLICOSANOL ON EXPERIMENTAL THROMBOSIS MODELS

Policosanol is a natural product, obtained from sugar cane wax (Saccha rum officinarum L.) with which cholesterol-lowering effects have been demonstrated in experimental models, healthy volunteers and hyperchole sterolemic patients. The effects of policosanol on experimental venous and arterial thrombosis in rats were investigated. Policosanol (25 mg /kg) significantly decreased the thrombus weight, in the venous thromb osis models, the protective effect persisting until 4 h after its oral administration. Policosanol (25 mg/kg single dose) was able to reduce rectal temperature variation induced by arterial thrombosis. Also at the same dose policosanol increased 6-keto-PGF(1 alpha), serum levels in rats.