D. Carbajal et al., EFFECT OF POLICOSANOL ON EXPERIMENTAL THROMBOSIS MODELS, Prostaglandins, leukotrienes and essential fatty acids, 50(5), 1994, pp. 249-251
Policosanol is a natural product, obtained from sugar cane wax (Saccha
rum officinarum L.) with which cholesterol-lowering effects have been
demonstrated in experimental models, healthy volunteers and hyperchole
sterolemic patients. The effects of policosanol on experimental venous
and arterial thrombosis in rats were investigated. Policosanol (25 mg
/kg) significantly decreased the thrombus weight, in the venous thromb
osis models, the protective effect persisting until 4 h after its oral
administration. Policosanol (25 mg/kg single dose) was able to reduce
rectal temperature variation induced by arterial thrombosis. Also at
the same dose policosanol increased 6-keto-PGF(1 alpha), serum levels
in rats.