MONOCLONAL-ANTIBODIES TO THE CIRCUMSPOROZOITE PROTEIN REPEATS OF A PLASMODIUM-VIVAX-LIKE HUMAN MALARIA PARASITE AND PLASMODIUM-SIMIOVALE

We have recently described a Plasmodium vivax-like human malaria paras ite. The circumsporozoite protein of this parasite is identical to tha t of a simian malaria parasite, P. simiovale, but different from two k nown types of P. vivax. Here, we describe the production of two monocl onal antibodies, Pam 172 and Pam 135, specific for the circumsporozoit e protein repeat sequence APGANQEGGAA of the P. vivax-like malaria par asite. These two monoclonal antibodies recognized air-dried sporozoite s of P. simiovale but not other human, simian, or rodent malaria paras ites tested.