INTERACTION BETWEEN MIANSERIN AND ACENOCOUMARIN - A SINGLE-CASE STUDY

A 62-year-old male patient, suffering from a hypertensive cardiopathy, an arteriopathy of the lower extremities and a type II insulin indepe ndent diabetes had a prothrombin time ratio R of 2.15 (therapeutic ran ge: 2.1-1.45) during a daily treatment of 4-6 mg acenocoumarin. On adm ission to the psychiatric hospital for depression, a mianserin treatme nt was commenced, leading to a sharp modification in the PT ratio R, i n effect that the acenocoumarin treatment had to be increased to keep R within the therapeutic range. The possible mechanism of this interac tion between mianserin and acenocoumarin is discussed, taking into acc ount the possible role of the comedicated amiodarone.