CHARACTERIZATION OF POLYMORPHISM AT THE H YPERVARIABLE REGION OF THE APOLIPOPROTEIN-B GENE IN VOLGA-URAL HUMAN-POPULATIONS

Data on the allelic polymorphism at the hypervariable locus 3' to the apolipoprotein B gene (ape B) in seven Turkic and Finno-Ugric human po pulations of the Volga-Ural region obtained by means of PCR method are presented. Sixteen allelic variants were distinguished, and the frequ ency distribution of alleles and genotypes across the populations stud ied were estimated. Alleles 34 and 36 appeared to be more common (from 13 to 45% in different populations); the calculated heterozygosity in dices ranged from 59.3 to 73.4%. Comparison of the data with that on o ther world populations made it possible to deduce some specific featur es of the alleles frequency distribution associated with geographic po sition of the population.