RETROSPECTIVE ESTIMATION OF THE HETEROZYG OUS BETA-THALASSEMIA FREQUENCY IN THE POPULATION OF CRIMEAN TARTARS - FORMULATION OF THE PROBLEM - ESTIMATION OF THE GAMETIC CONTRIBUTION TO A MIXED POPULATION FROM FREQUENCIES OF THE ABO BLOOD-GROUP GENES

Polymorphism of the beta-thalassemia gene frequency in nonindigenous p opulations of Central Asia, especially Crimean Tartars, is often expla ined by interethnic marriages, The frequencies of these marriages, how ever, are not sufficient to produce the observed gene frequencies. Bec ause of this, an estimation of the extent of Uzbec gametic contributio n to the ethnic group of Crimean Tartar origin was conducted using dat a on the frequencies of ABO blood group genes. The maximum-likelihood estimate obtained (0.325) was used to determine the heterozygous beta- thalassemia frequency of the ancestral Crimean Tartar population.