GENETIC-ASPECTS OF ENDOMETRIOSIS - PECULI ARITIES OF THE DISTRIBUTIONOF POLYMORPHIC GENE-FREQUENCY

In a group of patients with endometriosis and in a control group of he althy women, the polymorphism of the following systems were studied: A BO and RH blood-group systems; serum proteins haptoglobin (HP), transf errin (TF), vitamin D-transporting protein (GC), protease inhibitor (P I), and the third component of the complement (C'3); serum enzymes-amy lase of the loci 1 and 2 (AMY1 and AMY2), pseudocholinesterase (E2), a nd alkaline phosphatase (PP); erythrocytic enzymes-acid phosphatase (A CP1), phosphoglucomutase (PGM1), superoxide dismutase (SOD-A), esteras e D (ESD), and glyoxalase (GLO1). Statistically significant difference s between the groups compared were established for five genetic system s: ABO, E2, C'3, TF, and PGM1. Among patient with endometriosis, the r are alleles of the locus ESD-ESD(5) and ESD(7)-were found, along with ESD 5-5 homozygotes. Several genetic loci can be involved in the patho genesis of endometriosis; their products can be specifically realized due to peculiarities of biochemical reactions in the organisms of peop le predisposed to this pathology.