DYNAMICS OF HAPLOTYPE FREQUENCIES IN POPU LATIONS - STUDY BY THE MONTE-CARLO METHOD

A program that simulates random genetic drift, random mating, recombin ation, natural selection, and mutation process was developed to study the influence of these processes on the evolutionary dynamics of haplo type frequencies in populations. The program can track nine sites, eac h including up to 15 alleles. The program application was illustrated by the study of frequency dynamics in the HOXB haplotypes (17q) in dif ferent populations. The simulation results confirmed the hypothesis, w hich was proposed on the basis of the experimental data, that, in the absence of recurrent mutations, population mixing, and natural selecti on, the harmonic mean of the effective population size from the moment of New World colonization up to now was more than 1000.