Ge. Sonenshein, DOWN-MODULATION OF C-MYC EXPRESSION INDUCES APOPTOSIS OF B-LYMPHOCYTEMODELS OF TOLERANCE VIA CLONAL DELETION, The Journal of immunology, 158(5), 1997, pp. 1994-1997
Whereas overexpression of the c-myc gene was found to promote apoptosi
s in fibroblasts, myeloid, and T cells, physiologic cell death of imma
ture B cell lymphomas correlated with a drop in c-myc expression, Here
, the author reviews recent evidence demonstrating that inhibition of
c-myc expression activates apoptosis of B cell models of clonal deleti
on and that rescue from apoptosis by CD40 ligand leads to maintenance
of c-Myc levels, A model of differential functional expression of the
c-myc gene is discussed.