THE TISSUE HYDRATION STATE IN UW-PRESERVED HUMAN DONOR LIVERS - A CLINICAL-STUDY OF THE RELATION BETWEEN PROTON MAGNETIC-RESONANCE RELAXATION-TIMES, DONOR CONDITION, PRESERVATION PROCEDURE, AND EARLY GRAFT FUNCTION

Citation
Rfe. Wolf et al., THE TISSUE HYDRATION STATE IN UW-PRESERVED HUMAN DONOR LIVERS - A CLINICAL-STUDY OF THE RELATION BETWEEN PROTON MAGNETIC-RESONANCE RELAXATION-TIMES, DONOR CONDITION, PRESERVATION PROCEDURE, AND EARLY GRAFT FUNCTION, Transplantation, 57(8), 1994, pp. 1189-1194
Citations number
20
Categorie Soggetti
Immunology,Surgery
Journal title
ISSN journal
00411337
Volume
57
Issue
8
Year of publication
1994
Pages
1189 - 1194
Database
ISI
SICI code
0041-1337(1994)57:8<1189:TTHSIU>2.0.ZU;2-5
Abstract
To determine the relation between tissue hydration state-as indicated by tissue proton magnetic resonance relaxation times-in UW-preserved h uman donor livers and viability parameters of the donor and early graf t function, ''ex vivo'' magnetic resonance relaxometry was performed w ith a clinical MR imaging system. Relaxometric data were obtained from MR images in which signal intensities were directly proportional to T -1 and T-2. Forty three subsequently transplanted livers and five disc arded livers were studied. The donor serum concentrations of direct an d total bilirubin had a positive correlation with T-1 (P<0.05 and P<0. 01, respectively). Sequential measurements in 7 livers demonstrated a firm time relation between the cold storage time and the length of the relaxation times. As cold storage time lengthened, T-1 and T-2 shorte ned. T-1 of the donor liver showed a significant negative correlation with recipient ASAT and ALAT values on days 1, 2, and 3 after transpla ntation. T-1 in the discarded group was significantly higher than T-1 in the accepted group. T-2 was not different in the two groups. It is concluded that in UW-preserved human donor livers, the tissue hydratio n state, as indicated by the tissue MR relaxation times, is largely in dependent of the clinical condition of the organ donor and the preserv ation procedure. An optimum tissue hydration state, in UW-preserved do nors liver might have protective properties against parenchymal damage , although the clinical consequences appear to be of minor importance. The capacity of relaxometry as a discriminative instrument to accept or to discard donor livers is poor.