THE TISSUE HYDRATION STATE IN UW-PRESERVED HUMAN DONOR LIVERS - A CLINICAL-STUDY OF THE RELATION BETWEEN PROTON MAGNETIC-RESONANCE RELAXATION-TIMES, DONOR CONDITION, PRESERVATION PROCEDURE, AND EARLY GRAFT FUNCTION
Rfe. Wolf et al., THE TISSUE HYDRATION STATE IN UW-PRESERVED HUMAN DONOR LIVERS - A CLINICAL-STUDY OF THE RELATION BETWEEN PROTON MAGNETIC-RESONANCE RELAXATION-TIMES, DONOR CONDITION, PRESERVATION PROCEDURE, AND EARLY GRAFT FUNCTION, Transplantation, 57(8), 1994, pp. 1189-1194
To determine the relation between tissue hydration state-as indicated
by tissue proton magnetic resonance relaxation times-in UW-preserved h
uman donor livers and viability parameters of the donor and early graf
t function, ''ex vivo'' magnetic resonance relaxometry was performed w
ith a clinical MR imaging system. Relaxometric data were obtained from
MR images in which signal intensities were directly proportional to T
-1 and T-2. Forty three subsequently transplanted livers and five disc
arded livers were studied. The donor serum concentrations of direct an
d total bilirubin had a positive correlation with T-1 (P<0.05 and P<0.
01, respectively). Sequential measurements in 7 livers demonstrated a
firm time relation between the cold storage time and the length of the
relaxation times. As cold storage time lengthened, T-1 and T-2 shorte
ned. T-1 of the donor liver showed a significant negative correlation
with recipient ASAT and ALAT values on days 1, 2, and 3 after transpla
ntation. T-1 in the discarded group was significantly higher than T-1
in the accepted group. T-2 was not different in the two groups. It is
concluded that in UW-preserved human donor livers, the tissue hydratio
n state, as indicated by the tissue MR relaxation times, is largely in
dependent of the clinical condition of the organ donor and the preserv
ation procedure. An optimum tissue hydration state, in UW-preserved do
nors liver might have protective properties against parenchymal damage
, although the clinical consequences appear to be of minor importance.
The capacity of relaxometry as a discriminative instrument to accept
or to discard donor livers is poor.