Pn. Baker et Ga. Hackett, THE USE OF URINARY ALBUMIN-CREATININE RATIOS AND CALCIUM-CREATININE RATIOS AS SCREENING-TESTS FOR PREGNANCY-INDUCED HYPERTENSION, Obstetrics and gynecology, 83(5), 1994, pp. 745-749
Objective: To assess the potential of both urinary albumin-creatinine
ratios and urinary calcium-creatinine ratios as screening tests for pr
egnancy-induced hypertension. Methods: A prospective, non-intervention
al study was performed in a teaching hospital antenatal clinic. Five h
undred nonnotensive, nulliparous pregnant women provided a urine sampl
e at 19 weeks' gestation. The main outcome measurements were the devel
opment of pregnancy-induced hypertension and preeclampsia. Results: No
significant differences in urinary albumin/ creatinine and calcium/cr
eatinine were demonstrated between patients who developed pregnancy-in
duced hypertension and those who remained normotensive. Urinary creati
nine concentrations were significantly higher at 19 weeks' gestation i
n patients who subsequently developed pregnancy-induced hypertension.
Conclusions: This study suggests that neither urinary ratio is a poten
tial screening test for pregnancy-induced hypertension. The increased
urinary creatinine concentration in patients who subsequently develope
d pregnancy/induced hypertension has not previously been reported and
merits further investigation.