AN EVALUATION OF A NEW LACTIC-ACID POLYMER DRUG-DELIVERY SYSTEM - A PRELIMINARY-REPORT

A new drug delivery system, made of a mixture of DL-lactic acid polyme r and a copoly (L-lactic acid/delta-valerolactone) polymer (LAP) conta ining varying concentrations of Ofloxacin, has been evaluated. Results revealed that a LAP drug delivery system containing 0.03% Ofloxacin i nhibited the in vitro growth of clinically derived Staphylococcus aure us and Pseudomonas aeruginosa. Further, in an in vivo situation in rat s, at 1 week after the wound was inflicted, no infection was macroscop ically seen in split-thickness wounds that had been covered by LAP dru g delivery system containing 0.5 or 0.03% Ofloxacin, and more than 80% of the wound area had epithelialised.