Kc. Reddy et al., ANTITUMOR ETHER LIPIDS - AN IMPROVED SYNTHESIS OF ILMOFOSINE AND AN ENANTIOSELECTIVE SYNTHESIS OF AN ILMOFOSINE ANALOG, Tetrahedron letters, 35(17), 1994, pp. 2679-2682
Efficient routes to racemic Ilmofosine (1) and to the enantiomers of i
ts oxygen analog, 2'-(trimethylammonio)ethyl 3-hexadecyloxy-2-methoxym
ethylpropanephosphate (2), are described starting from ethyl alpha-(hy
droxymethyl)acrylate (3) or 2-methylene-1,3-propanediol (6).