BOVINE CONGLUTININ (BC) MESSENGER-RNA EXPRESSED IN LIVER - CLONING AND CHARACTERIZATION OF THE BC CDNA REVEALS STRONG HOMOLOGY TO SURFACTANT PROTEIN-D

Authors
LIOU LS SASTRY R HARTSHORN KL LEE YM OKARMA TB TAUBER AI SASTRY KN
Citation
Ls. Liou et al., BOVINE CONGLUTININ (BC) MESSENGER-RNA EXPRESSED IN LIVER - CLONING AND CHARACTERIZATION OF THE BC CDNA REVEALS STRONG HOMOLOGY TO SURFACTANT PROTEIN-D, Gene, 141(2), 1994, pp. 277-281
Citations number
34
Categorie Soggetti
Genetics & Heredity
Journal title
Gene → ACNP
ISSN journal
03781119
Volume
141
Issue
2
Year of publication
1994
Pages
277 - 281
Database
ISI
SICI code
0378-1119(1994)141:2<277:BC(MEI>2.0.ZU;2-U
Abstract
Bovine conglutinin (BC) is a C-type lectin isolated from bovine serum that appears to play a role in first-line host defense. The BC cDNA wa s cloned from a bovine liver library and the nucleotide (nt) sequence of 1519 bp was determined. The longest open reading frame encoded a 20 -amino-acid (aa) signal sequence and a mature protein of 351 aa. Analy sis of the nt and deduced aa sequences revealed 87 and 78% identity, r espectively, with the sequences of another vertebrate lectin: bovine s urfactant protein-D (SP-D). Of interest, the expression of the BC mRNA , as determined by RNase protection assay, is restricted to liver, unl ike bovine SP-D, a lung-surfactant protein.