Jy. Follezou, INTERACTION OF MITOXANTRONE WITH HEPARIN AND ITS APPLICATION TO THE QUANTITATION OF HEPARIN, Thrombosis research, 74(4), 1994, pp. 419-425
The interaction of heparin of high molecular weight with mitoxantrone,
an anthraquinone derivative, had been studied by spectrophotometry. H
eparin links the mitoxantrone and the binding sites are propably the a
nionic groups of the mucopolysaccharide since the linking is displaced
by Na+. This interaction of mitoxantrone with heparin could provides
a sensitive and simple method for quantitation of heparin in non prote
ic medium and could appear of clinical relevance in some circumstances
.