THE IGG2A ANTIBODY-RESPONSE TO THYROGLOBULIN IS LINKED TO THE IGH LOCUS IN MOUSE

Authors
KUPPERS RC EPSTEIN LD OUTSCHOORN IM ROSE NR
Citation
Rc. Kuppers et al., THE IGG2A ANTIBODY-RESPONSE TO THYROGLOBULIN IS LINKED TO THE IGH LOCUS IN MOUSE, Immunogenetics, 39(6), 1994, pp. 404-411
Citations number
30
Categorie Soggetti
Immunology,"Genetics & Heredity
Journal title
Immunogenetics → ACNP
ISSN journal
00937711
Volume
39
Issue
6
Year of publication
1994
Pages
404 - 411
Database
ISI
SICI code
0093-7711(1994)39:6<404:TIATTI>2.0.ZU;2-4
Abstract
The IgG-subclass usage by several strains of mice in the response to i mmunization with mouse thyroglobulin (mTg) was examined in the experim ental autoimmune thyroiditis model. While the subclass usage by most m ouse strains was similar, the Igh(b) allotype-bearing mice consistentl y produced lower IgG2a levels to mTg. Using CBA-Igh(b) congenic and re combinant inbred strains of mice, the lower level of IgG2a in the Igh( b) mouse was mapped to the Igh locus. The regulation of IgG2a appeared to be cis controlled, as the CBA x C57BL/6F(1) mouse also produced re duced IgG2a of the Igh(b) (B6) allotype but not of the Igh(j) (CBA) al lotype.