SYNTHESIS AND ANTICANCER ACTIVITY OF 2-SUBSTITUTED 2,3-DIHYDRO-1,3,2-BENZOXAZAPHOSPHORIN-4-ONE AND ITS 2-OXIDE DERIVATIVES

Authors
KOSTKA K PORADA M GRACZYK J
Citation
K. Kostka et al., SYNTHESIS AND ANTICANCER ACTIVITY OF 2-SUBSTITUTED 2,3-DIHYDRO-1,3,2-BENZOXAZAPHOSPHORIN-4-ONE AND ITS 2-OXIDE DERIVATIVES, Archiv der pharmazie, 327(4), 1994, pp. 233-236
Citations number
14
Categorie Soggetti
Chemistry,"Pharmacology & Pharmacy
Journal title
Archiv der pharmazie → ACNP
ISSN journal
03656233
Volume
327
Issue
4
Year of publication
1994
Pages
233 - 236
Database
ISI
SICI code
0365-6233(1994)327:4<233:SAAAO2>2.0.ZU;2-Y
Abstract
As a result of the reaction of salicylic amide with PCl3 and POCl3 chl oro-2,3-dihydro-1,3,2-benzoxazaphosphorin-4-one (1) and its 2-oxide 2 are Compounds 1 and 2 form amides with amines in 2-position. Antineopl astic action of the derivatives containing the bis(2-chloroethyl)amide group in 2-position was found.