To search for genes which encode human interferon receptor molecules,
we applied the technique of exon trapping to human chromosome 21 yeast
artificial chromosomes (YACs). A full length cDNA encoding human CRF2
-4 was identified which is shown here to be widely expressed in human
tissues. The human CRF2-4 cDNA was used as a probe to screen a mouse m
acrophage cDNA library. A mouse CRF2-4 cDNA was isolated which encodes
a 349-amino-acid (aa) polypeptide that is 69% identical at the aa lev
el with its human counterpart. Mouse CRF2-4 is predicted to be another
member of the interferon receptor-class II cytokine receptor family.