M. Maitre et al., DISPLACEMENT OF [H-3] GAMMA-HYDROXYBUTYRATE BINDING BY BENZAMIDE NEUROLEPTICS AND PROCHLORPERAZINE BUT NOT BY OTHER ANTIPSYCHOTICS, European journal of pharmacology, 256(2), 1994, pp. 211-214
Since gamma-hydroxybutyrate receptor agonists exhibit dopaminergic reg
ulatory properties and neuroleptic-like effects in neuropharmacologica
l tests, the common neuroleptics were tested for [H-3]gamma-hydroxybut
yrate binding activity on rat brain membranes. (-)-Sulpiride, sultopri
de, amisulpride and prochlorperazine possess affinity for the gamma-hy
droxybutyrate site(s), consistent with their therapeutic dosage. This
study has revealed that gamma-hydroxybutyrate receptors represent an a
dditional target for antipsychotics.