DISPLACEMENT OF [H-3] GAMMA-HYDROXYBUTYRATE BINDING BY BENZAMIDE NEUROLEPTICS AND PROCHLORPERAZINE BUT NOT BY OTHER ANTIPSYCHOTICS

Authors
MAITRE M RATOMPONIRINA C GOBAILLE S HODE Y HECHLER V
Citation
M. Maitre et al., DISPLACEMENT OF [H-3] GAMMA-HYDROXYBUTYRATE BINDING BY BENZAMIDE NEUROLEPTICS AND PROCHLORPERAZINE BUT NOT BY OTHER ANTIPSYCHOTICS, European journal of pharmacology, 256(2), 1994, pp. 211-214
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology → ACNP
ISSN journal
00142999
Volume
256
Issue
2
Year of publication
1994
Pages
211 - 214
Database
ISI
SICI code
0014-2999(1994)256:2<211:DO[GBB>2.0.ZU;2-3
Abstract
Since gamma-hydroxybutyrate receptor agonists exhibit dopaminergic reg ulatory properties and neuroleptic-like effects in neuropharmacologica l tests, the common neuroleptics were tested for [H-3]gamma-hydroxybut yrate binding activity on rat brain membranes. (-)-Sulpiride, sultopri de, amisulpride and prochlorperazine possess affinity for the gamma-hy droxybutyrate site(s), consistent with their therapeutic dosage. This study has revealed that gamma-hydroxybutyrate receptors represent an a dditional target for antipsychotics.