A ROLE FOR NITRIC-OXIDE IN THE ANTIULCER ACTIVITY OF CALCITONIN-GENE-RELATED PEPTIDE

Authors
CLEMENTI G CARUSO A PRATO A DEBERNARDIS E FIORE CE AMICOROXAS M
Citation
G. Clementi et al., A ROLE FOR NITRIC-OXIDE IN THE ANTIULCER ACTIVITY OF CALCITONIN-GENE-RELATED PEPTIDE, European journal of pharmacology, 256(2), 1994, pp. 180000007-180000008
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology → ACNP
ISSN journal
00142999
Volume
256
Issue
2
Year of publication
1994
Pages
180000007 - 180000008
Database
ISI
SICI code
0014-2999(1994)256:2<180000007:ARFNIT>2.0.ZU;2-M
Abstract
The anti-ulcer activity of calcitonin gene-related peptide (CORP) was inhibited, in a dose-dependent manner, by pretreatment with N-G-nitro- L-arginine methyl ester, an inhibitor of nitric oxide synthase. Our re sults suggest that endogenous nitric oxide is involved in the anti-ulc er activity of CGRP.