CONTRIBUTION OF MEMBRANE-ASSOCIATED CYTOTOXIC PROTEINS TO CYTOLYSIS OF L929 AND K562 TARGET-CELLS MEDIATED BY LAK CELLS WITH DIFFERENT PHENOTYPES

Authors
SASCHENKO LP GNUCHEV NV REDCHENKO IV KABANOVA OD LUKJIANOVA TI BLISHCHENKO LY SATPAEV DK CHERTOV OY
Citation
Lp. Saschenko et al., CONTRIBUTION OF MEMBRANE-ASSOCIATED CYTOTOXIC PROTEINS TO CYTOLYSIS OF L929 AND K562 TARGET-CELLS MEDIATED BY LAK CELLS WITH DIFFERENT PHENOTYPES, Immunology letters, 39(3), 1994, pp. 243-247
Citations number
18
Categorie Soggetti
Immunology
Journal title
Immunology letters → ACNP
ISSN journal
01652478
Volume
39
Issue
3
Year of publication
1994
Pages
243 - 247
Database
ISI
SICI code
0165-2478(1994)39:3<243:COMCPT>2.0.ZU;2-V
Abstract
We have demonstrated that the relative contribution of secreted and me mbrane-associated proteins to the cytotoxicity of LAK cells depended o n LAK cell phenotype: the cytotoxicity of CD16(+) CD8(+) CD3(-) LAK ce lls was associated mainly with membrane-bound proteins, and the activi ty of CD3(+) CD8(+) CD16(-) LAK cells was due mainly to secreted solub le proteins. The cytotoxic activity of membrane fractions of LAK cells against cell line L929 was determined by 40-, 32- and 21-kDa proteins for LAK cells bearing NK-specific markers and due to proteins of 34 a nd 21 kDa in the case of 'CTL-like' LAK-cells.