COMPARATIVE-STUDIES INTO 2 BORDETELLA-BRO NCHISEPTICA-LIVE VACCINES -ANIMAL-MODEL

Authors
KRUGER M REHAK E ZUCKER B KURSCHNER J HORSCH F
Citation
M. Kruger et al., COMPARATIVE-STUDIES INTO 2 BORDETELLA-BRO NCHISEPTICA-LIVE VACCINES -ANIMAL-MODEL, Monatshefte fur Veterinarmedizin, 49(3), 1994, pp. 127-133
Citations number
40
Categorie Soggetti
Veterinary Sciences
Journal title
Monatshefte fur Veterinarmedizin → ACNP
ISSN journal
00269263
Volume
49
Issue
3
Year of publication
1994
Pages
127 - 133
Database
ISI
SICI code
0026-9263(1994)49:3<127:CI2BNV>2.0.ZU;2-O
Abstract
Two Bordetella (B.) bronchiseptica live vaccines, Rhinicell(TM) and Bo rvicell-Dessau, were tested for their biological properties, colonizin g capability on nasal mucosa of guinea pig and rabbit as well as for t heir protective potentials for mouse, guinea pig and rabbit. The above B. bronchiseptica strains differed from each other particularly by ph ase stability in vivo. Borcivell-Dessau proved to be of high marker an d phase stability in all model investigations. Mouse and guinea pig, f or their inherent purine limitation, should not be used in tests of pu rine-auxotrophic bacterial strains. Intranasal Borvicell-Dessau immuni zation did not protect rabbit from Phase-I strain challenge infection, since the vaccine strain was present in a stable Phase III.