ACUTE HEPATIC AND RENAL TOXICITY FROM LOW-DOSES OF ACETAMINOPHEN IN THE ABSENCE OF ALCOHOL-ABUSE OR MALNUTRITION - EVIDENCE FOR INCREASED SUSCEPTIBILITY TO DRUG TOXICITY DUE TO CARDIOPULMONARY AND RENAL-INSUFFICIENCY

A 67-yr-old man with chronic cardiopulmonary disease exhibited severe hepatic and moderately severe renal injury after short-term ingestion of therapeutic doses of acetaminophen (1 to 3 gm/day for 3 days). Drug metabolism and other studies, performed 5 mo after recovery from the acute insult, indicated that the patient had decreased rates of hepati c metabolism of acetaminophen to its primary, nontoxic metabolites and decreased kidney function that was compromised further by acetaminoph en ingestion. He also had abnormally low concentrations of hepatic and plasma reduced glutathione. Alcohol abuse and malnutrition could not be implicated in the pathogenesis of injury; rather it appeared that a dvancing age with chronic renal, cardiac and pulmonary insufficiency c ontributed to acetaminophen toxicity in this patient.