MAPPING OF THE REGULATORY TYPE I-ALPHA AND CATALYTIC BETA-SUBUNITS OFCAMP-DEPENDENT PROTEIN-KINASE AND INTERLEUKIN-1-ALPHA AND 1-BETA IN THE PIG

Authors
MELLINK C LAHBIBMANSAIS Y YERLE M GELLIN J
Citation
C. Mellink et al., MAPPING OF THE REGULATORY TYPE I-ALPHA AND CATALYTIC BETA-SUBUNITS OFCAMP-DEPENDENT PROTEIN-KINASE AND INTERLEUKIN-1-ALPHA AND 1-BETA IN THE PIG, Mammalian genome, 5(5), 1994, pp. 298-302
Citations number
37
Categorie Soggetti
Biology,"Genetics & Heredity","Biothechnology & Applied Migrobiology
Journal title
Mammalian genome → ACNP
ISSN journal
09388990
Volume
5
Issue
5
Year of publication
1994
Pages
298 - 302
Database
ISI
SICI code
0938-8990(1994)5:5<298:MOTRTI>2.0.ZU;2-R
Abstract
The gene coding for the regulatory type I alpha subunit (PRKAR1A) and the catalytic beta subunit (PRKACB) of cAMP-dependent protein kinase a nd the genes for interleukin 1 alpha (IL1A) and interleukin 1 beta (IL 1B) were localized in the pig by means of radioactive in situ hybridiz ation. PRKAR1A was mapped to 12p1.4 and PRKARB to 6q3.1 --> q3.3. The genes for IL1A and IL1B were both assigned to Chromosome (Chr) 3, in t he region q1.2 --> q1.3 and q1.1 --> q1.4, respectively. The cDNA nucl eotide sequences of these porcine genes were compared with those of hu man, mouse and cattle. The location of the genes was discussed in rela tion to the position of their homologous loci in these mammalian speci es.