CHROMOSOMAL LOCALIZATION OF MOUSE AND HUMAN NEUROTENSIN RECEPTOR GENES

Neurotensin is a tridecapeptide that plays several neurotransmitter or neuromodulatory roles both in the central nervous system and in the p eriphery. These actions are mediated by a high-affinity receptor (Ntsr ). Both rat and human cDNAs encoding high-affinity receptors have been recently cloned. The availability of Ntsr probes allowed us to locali ze the corresponding genes on the mouse and human chromosomes. The pre sent data demonstrate that the Ntsr gene is assigned to the H region o f the mouse Chromosome (Chr) 2 and to the long arm of the human Chr 20 .