ACTIVITY OF EXTRACTS AND NAPHTHYLISOQUINOLINE ALKALOIDS FROM TRIPHYOPHYLLUM-PELTATUM, ANCISTROCLADUS-ABBREVIATUS AND A-BARTERI AGAINST PLASMODIUM-FALCIPARUM IN-VITRO
G. Francois et al., ACTIVITY OF EXTRACTS AND NAPHTHYLISOQUINOLINE ALKALOIDS FROM TRIPHYOPHYLLUM-PELTATUM, ANCISTROCLADUS-ABBREVIATUS AND A-BARTERI AGAINST PLASMODIUM-FALCIPARUM IN-VITRO, Phytochemistry, 35(6), 1994, pp. 1461-1464
Five extracts from the tropical plant species Triphyophyllum peltatum,
Ancistrocladus abbreviatus and A. barteri, and six pure naphthylisoqu
inoline alkaloids derived from these species have been examined for th
eir antiplasmodial activity. These species are well-known in the tradi
tional medicine of West Africa and are used for the treatment of fever
s, malaria and other diseases. The extracts and alkaloids were tested
against the asexual erythrocytic stages of two strains of Plasmodium f
alciparum in vitro (K1/chloroquine-resistant and NF 54/64, clone A1A9/
chloroquine-sensitive). Incorporation of H-3-hypoxanthine was measured
in the presence of the test substances after 42 hr of incubation at 3
7 degrees. All extracts and three alkaloids displayed activity. The tw
o most potent compounds were dioncopeltine A and dioncophylline B. Str
ucture-activity considerations indicate two possible criteria for anti
plasmodial activity: an R-configuration at C-3 associated with the abs
ence of an oxygen substituent at C-6 and the absence of N-methylation.