DISTRIBUTION OF PRION PROTEIN IN GERMAN PATIENTS WITH CREUTZFELDT-JAKOB-DISEASE IS DIFFERENT FROM THAT IN JAPANESE PATIENTS

Authors
DOIYI R KITAMOTO T OGOMORI K MEHRAEIN P TATEISHI J
Citation
R. Doiyi et al., DISTRIBUTION OF PRION PROTEIN IN GERMAN PATIENTS WITH CREUTZFELDT-JAKOB-DISEASE IS DIFFERENT FROM THAT IN JAPANESE PATIENTS, Acta Neuropathologica, 87(5), 1994, pp. 481-483
Citations number
22
Categorie Soggetti
Neurosciences
Journal title
Acta Neuropathologica → ACNP
ISSN journal
00016322
Volume
87
Issue
5
Year of publication
1994
Pages
481 - 483
Database
ISI
SICI code
0001-6322(1994)87:5<481:DOPPIG>2.0.ZU;2-1
Abstract
We investigated the distribution of prion protein (PrP) in 14 German p atients with sporadic Creutzfeldt-Jakob disease (CJD) and compared it with that observed in Japanese patients. Immunohistochemical study rev ealed diffuse gray matter stainings including synaptic structures in a ll cases. In addition, 4 patients showed plaque-type deposition which was very rarely observed among sporadic Japanese patients without know n mutation of the PrP gene but with valine at codon 129. A higher inci dence of PrP plaques in German sporadic CJD may be related to the raci al difference in the PrP gene.