THE T(14-18) IN A PATIENT WITH DE-NOVO ACUTE LYMPHOBLASTIC-LEUKEMIA IS ASSOCIATED WITH T(8-9)

Authors
LILLINGTON DM MONARD S JOHNSON PWM EVANS ML KEARNEY LU LISTER TA YOUNG BD GIBBONS B
Citation
Dm. Lillington et al., THE T(14-18) IN A PATIENT WITH DE-NOVO ACUTE LYMPHOBLASTIC-LEUKEMIA IS ASSOCIATED WITH T(8-9), Leukemia, 8(4), 1994, pp. 560-563
Citations number
19
Categorie Soggetti
Hematology,Oncology
Journal title
Leukemia → ACNP
ISSN journal
08876924
Volume
8
Issue
4
Year of publication
1994
Pages
560 - 563
Database
ISI
SICI code
0887-6924(1994)8:4<560:TTIAPW>2.0.ZU;2-P
Abstract
Cytogenetic analysis of a bone marrow aspirate from a patient with acu te lymphoblastic leukemia (ALL) revealed the presence of a complex kar yotype containing the translocation, t(14;18)(q32;q21). Further invest igations using fluorescence in situ hybridization (FISH) allowed the c haracterization of an additional translocation, t(8;9)(q24;p1?). The a ssociation of t(14;18)(q32;q21) and t(8;9)(q24;p13) has recently been described in two patients with de novo ALL (Nacheva et al. Blood 1993; 82:231-240) and this report supports these findings.