THE IMPORTANCE OF STUDYING CLONOGENIC PRO PERTIES OF MEDULLARY HEMATOPOIETIC-CELLS IN MULTIPLE-MYELOMA

The importance of studying clonogenic properties of medullary hemopoie tic cells in multiple myeloma. K. M. Abdulkadyrov, S. S. Bessmeltsev, V. A. Balashova. Research Institute of Hematology and Blood Transfusio n, St. Petersburg, Russia. The study of clonogenic properties of granu lo-monocytopoiesis cell-precursors (CFU-GM) in 47 multiple myeloma pat ients revealed that the lowest clonogenic activity of the bone marrow occurs in the initial stage of multiple myeloma and in the development of the disease relapse. In remission the pool of normal CFU-GM seemed much improved due to suppression of the tumor cell pool by cytostatic drugs. Clonogenic properties of the above cell-precursors may serve a valuable marker of the multiple myeloma treatment efficacy.