HEMOGLOBIN ROLE IN HYPOXIA ADAPTATION OF IRON-DEFICIENCY ANEMIA PATIENTS

Hemoglobin role in hypoxia adaptation of iron-deficiency anemia patien ts. M. G. Dmitrieva, I. V. Karpova, A. V. Pivnik, L. O. Gazenko, G. M. Valova. Hematological Research Center, Moscow, Russia. To define Hb r ole in compensation of hemic hypoxia, the authors studied HbO2 dissoci ation curves (HDC), blood acid-base equilibrium, concentrations of 2,3 -DPG and creatinin in red cells from females with moderate iron-defici ency anemia resultant from frequent haemorrhages. This form of anemia was found associated with a 34 % increase in the level of 2,3-DPG agai nst normal amounts of other two ligands essencial to Hb affinity to ox ygen, i. e. H+ ions and CO2. A 3-fold increase in creatinin concentrat ions and its direct relationship with 2,3-DPG quantitative characteris tics gave ground for considering rejuvenescence of the red cells in th e peripheral blood to be the underlying factor in enhancement of 2,3-D PG synthesis. A 2,3-DPG-induced in vivo HDC shift to the right by 2.5 mm Hg stimulates oxygen release from HbO2. The resultant 15 % addition al oxygen partially compensates for low Hb blood levels in the anemic patients.