NEPHROGENIC MECHANISM OF POSTTRAUMATIC HE MOLYSIS

Nephrogenic mechanism of posttraumatic hemolysis. L. I. Ershova, G. N. Kurbanova, V. L. Vinogradov, T. V. Batasheva. Hematological Research Center, Moscow. The crush-syndrome model was introduced for experiment al evaluation of the kidney-related mechanism of red cell destruction in an early posttraumatic period 1 day). Absolute and relative counts of the red cells, HCT were found reduced, while serum hemoglobin was o n the increase in rats with crush syndrome against the controls and ra ts subjected to trauma and nephrectomy. Renal perfusion in situ with s yngeneic blood brought about a decline in rat erythrocyte functional p erformance and a rise in the level of free hemoglobin. The findings su pport participation of the local nephrogenic hemolytic component in pa thogenesis of early posttraumatic anemia.