ON THE STRUCTURE OF MITOCHONDRIAL PORINS AND ITS HOMOLOGIES WITH BACTERIAL PORINS

By use of computer modelling, we have predicted a model of 16 transmem brane beta-strands for mitochondrial porins structure from human, Sacc haromyces cerevisiae, Neurospora crassa and Dictostelium discoideum. T he proposed model takes into account biochemical and immunological dat a reported in the literature, as well as electrophysiological results obtained with yeast mitochondrial porins with mutations at selected am ino acids. The predicted structure is very similar to that of some bac terial porins, as apparent from the homology of their hydropathic prof iles. (C) 1994 Academic Press, Inc.